The film's themes of friendship, love, and sacrifice resonated with audiences, making it a timeless classic. "Muqaddar Ka Sikandar" has been cited as an inspiration by numerous filmmakers and actors, including Rajkumar Santoshi, who credited the film as an influence on his 1991 film "Damini."

The film's cast is a testament to the prowess of Indian cinema's finest actors of the 1970s. Amitabh Bachchan, in the titular role of Sikandar, delivered a memorable performance, showcasing his range as an actor. Vinod Khanna, as Anand, brought a sense of vulnerability and camaraderie to the screen, forming a compelling on-screen duo with Bachchan. Rekha, in the role of Shamim, shone with her subtle yet impactful performance, adding a touch of elegance to the film. The supporting cast, including Neena Gupta and R.G. Vijayasarathy, added texture to the narrative, elevating the film's overall impact.

"Muqaddar Ka Sikandar" was released on April 29, 1978, under the banner of Prakash Mehra Productions. Directed by Prakash Mehra, the film boasted an all-star cast, including Amitabh Bachchan, Vinod Khanna, Rekha, Neena Gupta, and R.G. Vijayasarathy. The movie's narrative revolves around the lives of four friends - Sikandar (Amitabh Bachchan), Anand (Vinod Khanna), Shamim (Rekha), and Jagmohan (R.G. Vijayasarathy) - and their intertwined fates.